Clinical Outcomes Associated With Methylprednisolone in Mechanically Ventilated Patients With COVID-19
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A case-control study conducted by pharmacy, infectious disease, and pulmonary specialists from Columbia University Irving Medical Center on 117 mechanically ventilated COVID-19 patients, where the experimental group (n = 48) received methylprednisone within 14 days of admission showed that the methylprednisone group had significantly higher ventilator-free days (p = 0.044) and probability of extubation by day 28 (p = 0.087) compared to the control group (Table 2). Overall, these results indicate the effectiveness of corticosteroid treatment in severe COVID-19 patients requiring mechanical ventilation.
Summary
- The protocol dosage for methylprednisolone was one mg/kg/day with a max dose of 80 mg per day, with recommended duration of five days, although the course could be extended at the discretion of the treating physician. The protocol recommended that steroids only be started in patients at least five to seven days after symptom onset and only in those with evidence of systemic inflammation
- After controlling for age, SOFA score, white blood cell count, LDG, and D-dimer, multivariable linear regression analysis showed methylprednisone to be associated with improved outcome (p = 0.015) overall compared to hydroxychloroquine, azithromycin, or toclizumab
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High Frequency of SARS-CoV-2 RNAemia and Association With Severe Disease
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COVID-19-related coagulopathy: a review of pathophysiology and pharmaceutical management
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Characteristics and outcomes of in-hospital cardiac arrest in COVID-19. A systematic review and meta-analysis
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Hairy cell leukemia and COVID-19 adaptation of treatment guidelines
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